{"id":6678,"date":"2021-10-22T16:06:47","date_gmt":"2021-10-22T09:06:47","guid":{"rendered":"https:\/\/rosetta.vn\/nguyenxuanxanh\/?p=6678"},"modified":"2022-12-20T10:03:23","modified_gmt":"2022-12-20T03:03:23","slug":"nguyen-van-thang-phat-minh-dot-pha-co-tac-dung-chua-tri-ung-thu","status":"publish","type":"post","link":"https:\/\/rosetta.vn\/nguyenxuanxanh\/nguyen-van-thang-phat-minh-dot-pha-co-tac-dung-chua-tri-ung-thu\/","title":{"rendered":"Nguy\u1ec5n V\u0103n Th\u1eafng: Ph\u00e1t minh \u0111\u1ed9t ph\u00e1 c\u00f3 t\u00e1c d\u1ee5ng ch\u1eefa tr\u1ecb ung th\u01b0"},"content":{"rendered":"

NGUY\u1ec4N V\u0102N TH\u1eaeNG<\/span><\/p>\n

PH\u00c1T MINH \u0110\u1ed8T PH\u00c1 C\u00d3 T\u00c1C D\u1ee4NG <\/span><\/p>\n

CH\u1eeeA TR\u1eca UNG TH\u01af<\/span><\/p>\n

Nguy\u1ec5n Xu\u00e2n Xanh gi\u1edbi thi\u1ec7u<\/em><\/span><\/p>\n

\u0110\u1ea7u th\u00e1ng 10, 2021, m\u1ed9t lo\u1ea1t b\u00e1o khoa h\u1ecdc n\u01b0\u1edbc ngo\u00e0i \u0111\u01b0a tin: M\u1ed9t nh\u00e0 nghi\u00ean c\u1ee9u t\u1ea1i \u0110\u1ea1i h\u1ecdc Y khoa Missouri, Columbia, \u0111\u00e3 ph\u00e1t hi\u1ec7n ra m\u1ed9t lo\u1ea1i enzyme \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng khi\u1ebfn cho c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 kh\u00e1ng l\u1ea1i thu\u1ed1c \u0111i\u1ec1u tr\u1ecb. \u0110\u00f3 l\u00e0 Nguy\u1ec5n V\u0103n Th\u1eafng, DVM, PhD<\/a>. C\u00f4ng tr\u00ecnh n\u00e0y \u0111\u01b0\u1ee3c b\u00ecnh duy\u1ec7t b\u1edfi nhi\u1ec1u nh\u00e0 khoa h\u1ecdc t\u00ean tu\u1ed5i, trong \u0111\u00f3 c\u00f3 nhi\u1ec1u ng\u01b0\u1eddi \u0111\u01b0\u1ee3c gi\u1ea3i Nobel. Ng\u01b0\u1eddi ch\u1ecbu tr\u00e1ch nhi\u1ec7m bi\u00ean t\u1eadp l\u00e0 Vishva Mitra Dixit, b\u00e1c s\u0129 v\u00e0 hi\u1ec7n l\u00e0 Ph\u00f3 Ch\u1ee7 t\u1ecbch B\u1ed9 ph\u1eadn Nghi\u00ean c\u1ee9u Kh\u00e1m ph\u00e1 t\u1ea1i c\u00f4ng ty Genentech. M\u1ecdi s\u1ef1 ki\u1ec3m tra \u0111\u1ec1u nghi\u00eam ng\u1eb7t \u0111\u1ec3 b\u1ea3o \u0111\u1ea3m ch\u1ea5t l\u01b0\u1ee3ng c\u1ee7a m\u1ed9t c\u00f4ng tr\u00ecnh nghi\u00ean c\u1ee9u c\u00f3 \u1ea3nh h\u01b0\u1edfng l\u1edbn tr\u01b0\u1edbc khi \u0111\u01b0\u1ee3c c\u00f4ng b\u1ed1.<\/p>\n

T\u1eeb tr\u01b0\u1edbc t\u1edbi nay, c\u00e1c lo\u1ea1i thu\u1ed1c \u0111i\u1ec1u h\u00f2a mi\u1ec5n d\u1ecbch nh\u01b0 thalidomide, lenalidomide v\u00e0 pomalidomide \u0111\u01b0\u1ee3c bi\u1ebft \u0111\u00e3 c\u1ea3i thi\u1ec7n vi\u1ec7c \u0111i\u1ec1u tr\u1ecb cho b\u1ec7nh nh\u00e2n \u0111a u t\u1ee7y v\u00e0 c\u00e1c b\u1ec7nh ung th\u01b0 m\u00e1u kh\u00e1c. Nh\u01b0ng h\u1ea7u h\u1ebft t\u1ea5t c\u1ea3 c\u00e1c b\u1ec7nh nh\u00e2n cu\u1ed1i c\u00f9ng \u0111\u1ec1u ph\u00e1t tri\u1ec3n kh\u1ea3 n\u0103ng kh\u00e1ng l\u1ea1i<\/em> c\u00e1c li\u1ec7u ph\u00e1p n\u00e0y. C\u01a1 ch\u1ebf kh\u00e1ng thu\u1ed1c n\u00e0y di\u1ec5n ra nh\u01b0 th\u1ebf n\u00e0o, v\u00e0 l\u00e0m sao \u0111\u1ec3 kh\u1ed1ng ch\u1ebf n\u00f3? \u0110\u00f3 l\u00e0 m\u1ee5c ti\u00eau m\u00e0 anh Th\u1eafng \u0111\u00e3 \u0111eo \u0111u\u1ed5i su\u1ed1t nhi\u1ec1u n\u0103m qua. Anh hi\u1ec7n l\u00e0 gi\u00e1o s\u01b0 tr\u1ee3 l\u00fd t\u1ea1i Trung t\u00e2m Y h\u1ecdc Ch\u00ednh x\u00e1c c\u1ee7a \u0110\u1ea1i h\u1ecdc Missouri.<\/p>\n

\"\"<\/p>\n

Nguy\u1ec5n V\u0103n Th\u1eafng<\/p>\n

Ph\u00e1t hi\u1ec7n \u0111\u1ed9t ph\u00e1 c\u1ee7a anh l\u00e0 m\u1ed9t lo\u1ea1i protein c\u00f3 t\u00ean USP15 v\u1ed1n t\u1ed3n t\u1ea1i r\u1ea5t nhi\u1ec1u trong c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 l\u00e0 nguy\u00ean c\u1edb c\u1ee7a s\u1ef1 \u0111\u1ec1 kh\u00e1ng v\u1edbi c\u00e1c lo\u1ea1i thu\u1ed1c \u0111i\u1ec1u h\u00f2a mi\u1ec5n d\u1ecbch n\u00f3i tr\u00ean. Anh \u0111\u00e3 v\u00e9n l\u00ean b\u1ee9c m\u00e0n b\u00ed m\u1eadt c\u1ee7a c\u01a1 ch\u1ebf kh\u00e1ng thu\u1ed1c c\u1ee7a c\u00e1c t\u1ebf b\u00e0o ung th\u01b0:<\/p>\n

\u201cLo\u1ea1i protein USP15 n\u00e0y b\u1ea3o v\u1ec7 t\u1ebf b\u00e0o ung th\u01b0 kh\u1ecfi b\u1ecb ph\u00e1 h\u1ee7y b\u1eb1ng c\u00e1ch lo\u1ea1i b\u1ecf c\u00e1c th\u1ebb ubiquitin \u0111\u01b0\u1ee3c c\u00e1c lo\u1ea1i thu\u1ed1c \u0111i\u1ec1u h\u00f2a mi\u1ec5n d\u1ecbch \u0111\u1eb7t tr\u00ean \u0111\u00f3. Nh\u1eefng th\u1ebb \u0111\u00f3 s\u1ebd d\u1eabn \u0111\u1ebfn qu\u00e1 tr\u00ecnh h\u1ee7y di\u1ec7t t\u1ebf b\u00e0o ung th\u01b0. Nh\u01b0ng n\u1ebfu c\u00e1c th\u1ebb \u0111\u00f3 b\u1ecb USP15 lo\u1ea1i b\u1ecf, c\u00e1c t\u1ebf b\u00e0o ung th\u01b0 s\u1ebd ti\u1ebfp t\u1ee5c ph\u00e1t tri\u1ec3n v\u00e0 nh\u00e2n l\u00ean.”<\/p>\n

Anh Th\u1eafng n\u00f3i: \u201cC\u00f4ng tr\u00ecnh nghi\u00ean c\u1ee9u n\u00e0y c\u00f3 th\u1ec3 gi\u00fap ch\u00fang ta kh\u00e1m ph\u00e1 ra li\u1ec7u m\u1ed9t ch\u1ea5t \u1ee9c ch\u1ebf USP15 (-inhibitor) k\u1ebft h\u1ee3p v\u1edbi c\u00e1c lo\u1ea1i thu\u1ed1c kh\u00e1c s\u1ebd hi\u1ec7u qu\u1ea3 h\u01a1n \u0111\u1ec3 \u0111i\u1ec1u tr\u1ecb ung th\u01b0 hay kh\u00f4ng. C\u00e1c nghi\u00ean c\u1ee9u s\u00e2u h\u01a1n s\u1ebd c\u1ea7n thi\u1ebft \u0111\u1ec3 x\u00e1c \u0111\u1ecbnh s\u1ef1 k\u1ebft h\u1ee3p t\u1ed1t nh\u1ea5t \u0111\u1ec3 c\u1ea3i thi\u1ec7n k\u1ebft qu\u1ea3 l\u00e2m s\u00e0ng c\u1ee7a b\u1ec7nh nh\u00e2n \u0111a u t\u1ee7y v\u00e0 c\u00e1c lo\u1ea1i ung th\u01b0 kh\u00e1c.”<\/p>\n

B\u00e0i b\u00e1o nghi\u00ean c\u1ee9u c\u1ee7a anh, g\u1ed3m 9 trang ch\u00ednh v\u00e0 10 trang ph\u1ee5, \u0111\u00e3 \u0111\u01b0\u1ee3c \u0111\u0103ng tr\u00ean t\u1ea1p ch\u00ed PNAS c\u1ee7a H\u00e0n l\u00e2m vi\u1ec7n Khoa h\u1ecdc Hoa K\u1ef3 ng\u00e0y 5, th\u00e1ng 10, 2021:<\/p>\n

https:\/\/www.pnas.org\/content\/118\/40\/e2111391118<\/a><\/p>\n

M\u1ed9t c\u00f4ng tr\u00ecnh \u0111\u1ed3 s\u1ed9 \u0111\u01b0\u1ee3c t\u1ea1o ra b\u1edfi m\u1ed9t t\u00e1c gi\u1ea3 duy nh\u1ea5t. PNAS l\u00e0 Proceedings of the National Academy of Sciences t\u1ea1p ch\u00ed ch\u00ednh th\u1ee9c c\u1ee7a H\u00e0n l\u00e2m vi\u1ec7n Khoa h\u1ecdc Qu\u1ed1c gia Hoa K\u1ef3 (NAS), l\u00e0 m\u1ed9t ngu\u1ed3n c\u00f3 th\u1ea9m quy\u1ec1n v\u1ec1 c\u00e1c nghi\u00ean c\u1ee9u g\u1ed1c, c\u00f3 t\u00e1c \u0111\u1ed9ng cao, bao g\u1ed3m r\u1ed9ng r\u00e3i c\u00e1c ng\u00e0nh khoa h\u1ecdc, sinh h\u1ecdc, v\u1eadt l\u00fd v\u00e0 x\u00e3 h\u1ed9i.<\/p>\n

<\/p>\n

 <\/p>\n

<\/p>\n

Hai trong nhi\u1ec1u s\u01a1 \u0111\u1ed3 minh h\u1ecda trong b\u00e0i b\u00e1o l\u1ecbch s\u1eed c\u1ee7a Nguy\u1ec5n V\u0103n Th\u1eafng tr\u00ean PNAS<\/p>\n

https:\/\/www.pnas.org\/doi\/10.1073\/pnas.2111391118<\/a><\/p>\n

\u201cT\u00f4i \u0111\u1ecdc b\u1ea3n th\u1ea3o (b\u00e0i b\u00e1o) nh\u01b0 m\u1ed9t c\u00e2u chuy\u1ec7n c\u1ed5 t\u00edch.\u201d<\/p>\n

 <\/p>\n

T\u1edd Thanh Ni\u00ean<\/em> \u0111\u00e3 r\u1ea5t nhanh nh\u1eb9n \u0111\u0103ng l\u1ea1i th\u00e0nh t\u1ef1u n\u00e0y t\u1ea1i \u0111\u00e2y ng\u00e0y 17 th\u00e1ng 10:<\/p>\n

https:\/\/thanhnien.vn\/nghien-cuu-dot-pha-ve-ung-thu-cua-nha-khoa-hoc-viet-post1391752.html?fbclid=IwAR29NBSZuYBi65c8vYVL37W-driDg9MT97N0dQDFI1jLp84phL0PPLki31M<\/a><\/p>\n

T\u1edd b\u00e1o vi\u1ebft:<\/p>\n

T\u1ed1t nghi\u1ec7p ng\u00e0nh b\u00e1c s\u0129 th\u00fa y t\u1ea1i \u0110\u1ea1i h\u1ecdc N\u00f4ng nghi\u1ec7p I (nay l\u00e0 H\u1ecdc vi\u1ec7n N\u00f4ng nghi\u1ec7p Vi\u1ec7t Nam), \u00f4ng Th\u1eafng \u1edf l\u1ea1i tr\u01b0\u1eddng l\u00e0m c\u00e1n b\u1ed9 gi\u1ea3ng d\u1ea1y. N\u0103m 2001, \u00f4ng theo h\u1ecdc th\u1ea1c s\u0129 sinh h\u1ecdc ph\u00e2n t\u1eed t\u1ea1i B\u1ec9 nh\u1edd \u0111\u1ec1 \u00e1n 322 c\u1ee7a Ch\u00ednh ph\u1ee7 Vi\u1ec7t Nam. Sau \u0111\u00f3, \u00f4ng sang M\u1ef9 theo h\u1ecdc b\u1ed5ng c\u1ee7a Qu\u1ef9 Gi\u00e1o d\u1ee5c Vi\u1ec7t Nam (VEF) \u0111\u1ec3 ho\u00e0n th\u00e0nh ch\u01b0\u01a1ng tr\u00ecnh ti\u1ebfn s\u0129 v\u1ec1 mi\u1ec5n d\u1ecbch h\u1ecdc v\u00e0 sinh h\u1ecdc ung th\u01b0.<\/p>\n

Xu\u1ea5t ph\u00e1t \u0111i\u1ec3m l\u00e0 b\u00e1c s\u0129 th\u00fa y, nh\u01b0ng h\u01b0\u1edbng nghi\u00ean c\u1ee9u ch\u00ednh hi\u1ec7n t\u1ea1i c\u1ee7a \u00f4ng l\u00e0 mi\u1ec5n d\u1ecbch h\u1ecdc v\u00e0 ung th\u01b0. Trao \u0111\u1ed5i v\u1edbi Thanh Ni\u00ean<\/em>, \u00f4ng Th\u1eafng cho bi\u1ebft m\u00ecnh ch\u1ecdn ng\u00e0nh n\u00e0y v\u00ec s\u1ef1 y\u00eau th\u00edch t\u00ecm t\u00f2i, kh\u00e1m ph\u00e1 c\u1ee7a m\u1ed9t nh\u00e0 khoa h\u1ecdc. \u201cT\u00f4i lu\u00f4n \u0111\u1eb7t c\u00e2u h\u1ecfi v\u1ec1 m\u1ecdi th\u1ee9 xung quanh v\u00e0 kh\u00f4ng mu\u1ed1n ch\u1ec9 d\u1eebng l\u1ea1i \u1edf \u0111\u1ed9ng v\u1eadt hay th\u1ef1c v\u1eadt. B\u00ean c\u1ea1nh \u0111\u00f3, t\u00f4i nh\u1eadn th\u1ea5y nghi\u00ean c\u1ee9u ung th\u01b0 v\u00e0 mi\u1ec5n d\u1ecbch gi\u00fap \u00edch cho c\u1ed9ng \u0111\u1ed3ng r\u1ea5t nhi\u1ec1u\u201d, \u00f4ng Th\u1eafng n\u00f3i th\u00eam.<\/p>\n

T\u00f4i n\u00f3i \u0111\u00f9a v\u1edbi Th\u1eafng r\u1eb1ng 355 n\u0103m tr\u01b0\u1edbc, 1665, nh\u1edd ch\u1ea1y d\u1ecbch t\u1ea3 ho\u00e0nh h\u00e0nh Lu\u00e2n \u0111\u00f4n v\u00e0 \u0111e d\u1ecda m\u1ed9t s\u1ed1 th\u00e0nh ph\u1ed1 Anh qu\u1ed1c, m\u1ed9t sinh vi\u00ean \u0111\u00e3 r\u1eddi \u0110\u1ea1i h\u1ecdc Cambridge lui v\u1ec1 v\u00f9ng qu\u00ea s\u1ed1ng t\u1ea1i gia trang c\u1ee7a b\u1ed1 m\u1eb9 \u0111\u1ec3 tr\u00e1nh d\u1ecbch, v\u00e0 ch\u1ec9 trong hai n\u0103m sinh vi\u00ean \u0111\u00f3 \u0111\u00e3 c\u00f3 nh\u1eefng kh\u00e1m ph\u00e1 v\u0129 \u0111\u1ea1i nh\u1ea5t th\u1eddi \u0111\u1ea1i. \u0110\u00f3 l\u00e0 Isaac Newton. Nay trong tr\u1eadn d\u1ecbch l\u1ecbch s\u1eed covid-19 c\u00f3 m\u1ed9t ng\u01b0\u1eddi Vi\u1ec7n Nam th\u00edch s\u1ed1ng th\u01b0 gi\u00e3n b\u1eb1ng hobby c\u00e2u c\u00e1, v\u00e0 \u0111\u00e3 l\u00e0m m\u1ed9t kh\u00e1m ph\u00e1 to l\u1edbn cho th\u1ebf gi\u1edbi.<\/p>\n

Sau c\u00f4ng b\u1ed1 n\u00e0y, cu\u1ed9c c\u1ea1nh tranh quy\u1ebft li\u1ec7t gi\u1eefa c\u00e1c c\u00f4ng ty b\u00e0o ch\u1ebf d\u01b0\u1ee3c ph\u1ea9m, v\u00e0 c\u00e1c ph\u00f2ng nghi\u00ean c\u1ee9u tr\u00ean th\u1ebf gi\u1edbi s\u1ebd di\u1ec5n ra \u0111\u1ec3 t\u1ea1o c\u00e1c USP15 inhibitor \u0111\u1eb7c hi\u1ec7u, t\u1eeb \u0111\u00f3 l\u00e0m li\u1ec7u ph\u00e1p h\u1ed7n h\u1ee3p: nh\u01b0 Thalidomide + USP15 inhibitor, \u0111i\u1ec1u tr\u1ecb cho hi\u1ec7u qu\u1ea3. Ai l\u00e0m \u0111\u01b0\u1ee3c s\u1ebd chi\u1ebfn th\u1eafng.<\/p>\n

Anh Th\u1eafng t\u00e2m s\u1ef1: \u201c\u0111\u00e3 vi\u1ebft b\u00e0i b\u00e1o m\u1ed9t m\u1ea1ch 72 gi\u1edd kh\u00f4ng ng\u1ee7!\u201d V\u00e0 m\u1ed9t trong nh\u1eefng ng\u01b0\u1eddi \u0111\u1ecdc \u0111\u00e3 b\u00ecnh lu\u1eadn:\u00a0 \u201cT\u00f4i \u0111\u1ecdc b\u1ea3n th\u1ea3o nh\u01b0 m\u1ed9t c\u00e2u chuy\u1ec7n c\u1ed5 t\u00edch.\u201d C\u00f3 th\u1ec3 n\u00f3i, sau ba n\u0103m l\u00e0m vi\u1ec7c t\u1ea1i \u0110\u1ea1i h\u1ecdc Missouri, k\u1ebft qu\u1ea3 tr\u00ean l\u00e0 tr\u1ecdn v\u1eb9n cho c\u1ea3 qu\u00e1 tr\u00ecnh nghi\u00ean c\u1ee9u ki\u00ean tr\u00ec nhi\u1ec1u n\u0103m c\u1ee7a anh t\u1eeb nh\u1eefng n\u0103m c\u00f2n l\u00e0m vi\u1ec7c \u1edf Vi\u1ec7n Caltech, California.<\/p>\n

\"\"<\/p>\n

\u1ea2nh Gi\u00e1o s\u01b0 Ralph Steinman trao Gi\u1ea3i \u201cOutstanding Immunologist\u201d n\u0103m 2006 cho anh Th\u1eafng t\u1ea1i Texas. (\u1ea2nh \u0111\u01b0\u1ee3c \u0110\u1eb7ng \u0110\u00ecnh Thi cung c\u1ea5p.) N\u0103m n\u0103m sau 2011, GS Ralph Steinman \u0111\u01b0\u1ee3c trao gi\u1ea3i th\u01b0\u1edfng Nobel trong Y h\u1ecdc (1\/2 gi\u1ea3i Nobel; Bruce Beutler v\u00e0 Jules Hoffmann 1\/2 c\u00f2n l\u1ea1i). Ti\u1ebfc r\u1eb1ng khi c\u00f3 cu\u1ed9c g\u1ecdi quan tr\u1ecdng t\u1eeb Thu\u1ef5 \u0110i\u1ec3n \u0111\u1ec3 th\u00f4ng b\u00e1o cho \u00f4ng \u1ea5y, th\u00ec ng\u01b0\u1eddi \u0111\u1ea1i di\u1ec7n m\u1edbi ng\u1ee1 ra r\u1eb1ng GS Ralph Steinman v\u1eeba m\u1ea5t 3 ng\u00e0y tr\u01b0\u1edbc! (Tuy nhi\u00ean, \u1ee6y Ban Nobel v\u1eabn gi\u1eef v\u1eefng quy\u1ebft \u0111\u1ecbnh c\u1ee7a m\u00ecnh nh\u01b0 m\u1ed9t ngo\u1ea1i l\u1ec7.) “Mong r\u1eb1ng c\u00e1i “h\u01a1i h\u00e1m” Nobel s\u1ebd mang nh\u1eefng \u0111i\u1ec1u k\u1ef3 di\u1ec7u cho b\u1ea1n c\u1ee7a m\u00ecnh! Who knows?” (\u0110\u1eb7ng \u0110\u00ecnh Thi)<\/p>\n

Ngo\u00e0i ra anh c\u00f2n nh\u1eadn \u0111\u01b0\u1ee3c m\u1ed9t s\u1ed1 gi\u1ea3i th\u01b0\u1edfng quan tr\u1ecdng, trong \u0111\u00f3 c\u00f3<\/p>\n